A novel therapeutic regime to eradicate established solid tumors with an effective induction of tumor-specific immunity Short title: Sequential use of two oncolytic viruses for cancer treatment
نویسندگان
چکیده
Sino-British Research Center for Molecular Oncology, Zhengzhou University, People’s Republic of China. 2 Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary, University of London, UK; 3 CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences; 4 Department of Pathology, Beijing An Zhen Hospital, Capital Medical University, Beijing, People’s Republic of China. * Equal contribution
منابع مشابه
A novel therapeutic regimen to eradicate established solid tumors with an effective induction of tumor-specific immunity.
PURPOSE The efficacy of oncolytic viruses depends on multiple actions including direct tumor lysis, modulation of tumor perfusion, and stimulation of tumor-directed immune responses. In this study, we investigated whether a sequential combination of immunologically distinct viruses might enhance antitumor efficacy through the induction of tumor-specific immunity and circumvention or mitigation ...
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PURPOSE Advanced-stage cancers are extremely difficult to treat and rarely result in a cure. The application of oncolytic viruses is a potential strategy for controlling advanced-stage cancer because intratumoral (i.t.) injection of an oncolytic virus, such as vaccinia virus, results in tumor cell lysis and subsequent release of tumor antigens into the microenvironment. Furthermore, the viruses...
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تاریخ انتشار 2012